There many studies on the relationship between cannabis use and mental illnesses. Cannabis is potentially a medicine box, it has so many various cannabinoids and it offers new ways to treat mental illness.


Biologically, cannabinoids are chemical compounds that can interact, in any or another way, with cannabinoid receptors. Such compounds can be classified into cannabimimetics—they exhibit cannabinoid action and are mostly CB1 receptor agonists, and antagonists competent of coupling to cannabinoid receptors— they provide no cannabinoid effects, simply blocking these receptors for other substances. The term “cannabinoids” covers compounds having diverse chemical structures underlying the conventional classification.

There are more than 80 cannabinoids. The Tetrahydrocannabinol (THC), the best examined and possibly the most psychoactive ingredient in marijuana and cannabidiol (CBD) have opposing results, and different genetic or strains like chemdawg 4 or Nirvana seeds OG kush have different levels of cannabinoids.

Cannabinoids exist largely in the plant as their carboxylic precursors Tetrahydrocannabinolic acid and Cannabidiolic acid and are decarboxylated by light or heat while in storage or when combusted. Tetrahydrocannabinol (THC) is synthesized inside the secretory trichomes present in the flowers, leaves, and branch of the female plant. It yields a common precursor, olivetoic acid, with another quantitatively important component of Cannabis sativa, cannabidiol (CBD), which is the amplest cannabinoid in hemp. For this reason, the genetic profile and relative level of representation of the enzymes responsible for their synthetic genotype, namely THCA synthase and CBDA synthase, define the chemical composition of a particular cultivar (chemotype).

Alzheimer’s disease

Recent medical research suggests that the use of medical marijuana could play a significant role in reducing the progression of the dreaded Alzheimer’s disease. Tetrahydrocannabinol or THC that is its primary ingredient reduces and prevents the formation of neural protein deposits deep within the brain. These deposits are primarily responsible for this degenerative neural condition. Medical cannabis that is supplied by medical marijuana dispensaries control the formation of these protein deposits or sticky amyloid plaques that result in neuronal damage, inhibits memory and cognition, cause severe loss of memory, and lead to confusion, irritability, mood swings, spatial disorientation, and speech problems.

The progressive and fatal Alzheimer’s disease destroys brain cells, which results in loss of memory, dementia, and disturbed motor skills along with diminished intellect and social skills. Alzheimer’s disease is among the top ten causes of death in the elderly in the United States. Research indicates that medical cannabis represents an effective drug treatment for Alzheimer’s disease and some of its symptoms.


Cannabis is very helpful for anxiety, which is often experienced by patients dealing with cancer, chronic pain, and other conditions for which marijuana is helpful. Medical marijuana may slow down thought processes, helping break up some of the upsetting thought patterns that anxiety sufferers have to deal with.

Marijuana users in general, report fewer episodes of depression than non-smokers. Usage in depression can help break up negative thought cycles that may lead to a debilitating episode. Marijuana does not magically treat depression and will not cure the root problem leading to it. However, it can help considerably with mood while the patient works with a professional to treat the root cause.

Medical marijuana may calm mood swings substantially that are seen with bipolar disorder. Medical marijuana helps with these numerous mental conditions substantially. It provides an excellent alternative to traditional medications which often have considerable side effects and may have substantial costs as well.



Depression is one of the nation’s most well-known mental health disorders. Across the many depressive disorders that exist like persistent depressive disorder, major depressive disorder and, premenstrual dysphoric disorder there are common symptomatic traits of feelings of sadness, emptiness, or irritable mood, accompanied by bodily and cognitive changes that affect the individual’s capacity to function. The endocannabinoid system is known to play a role in mood regulation.

Sleep disorders

Sleep disorders can be categorized into principal groups that include insomnia, sleep-related breathing disorders, parasomnias, sleep-related movement disorders, and circadian rhythm sleep-wake disorders. There is some data to recommend that the endocannabinoid system may have a role in sleep. THC is correlated in a dose-dependent manner with changes in slow-wave sleep, which is crucial for learning and memory consolidation. Cannabinoids may also have effects on sleep latency, reducing time to sleep onset at low doses and improving time to sleep onset at higher doses. Thus, cannabinoids could have a role in treating sleep disorders.

Posttraumatic stress disorder (PTSD)

Posttraumatic stress disorder (PTSD) trips inside a broader trauma- and stressor-related ailments categorized by the Diagnostic and Statistical Manual of Mental Disorders. The diagnostic criteria of PTSD involve an exposure to a traumatic event like the threat of death, serious injury, or sexual violence and presenting a psychological distress symptoms that occur as a result of that vulnerability like the intrusion symptoms, such as distressing memories; delay of stimuli that are associated with the traumatic event; adverse alterations in mood and cognition; changes in arousal and reactivity associated with the traumatic event; functional impairment.


Given the known psychoactive effects of some cannabinoids, trials and studies on the effects of different types of cannabis with varying Mephisto genetics THC and CBD content on mental disorder symptoms gives a promising medical potential. The result adds substantially to the information center, expanding the range of cannabinoids evaluated and the possibility to examine the consistency of effects beyond studies.

Natalie Gray is a Biochemical Engineer. She works in the Research and Development team that focuses on the design and construction of unit processes. She is a recreational marijuana supporter and her love for organic chemistry brought her to medical cannabis. She grows her own flowers, working on different projects and study everything above and under cannabis roots.